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Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Interv+Card+Electrophysiol 2020 ; 59 (2): 315-320 Nephropedia Template TP
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Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment Updatable in accordance with the availability of new evidence #MMPMID32418181
Asensio E; Acunzo R; Uribe W; Saad EB; Saenz LC
J Interv Card Electrophysiol 2020[Nov]; 59 (2): 315-320 PMID32418181show ga
COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. Although the clinical evidence supporting their use is scarce, the off label use of these drugs has spread very quickly in face of the progression of the epidemic and the high mortality rate in susceptible populations. However, these medications can pathologically prolong the QT interval and lead to malignant ventricular arrhythmias such that organized guidance on QT evaluation and management strategies are important to reduce morbidity associated with the potential large-scale use.