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10.1016/j.virusres.2020.198022 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198022 32417181!7228740!32417181     free     free     free       Virus+Res 2020 ; 285 (ä): 198022 Nephropedia Template TP {{tp|p=32417181|t=2020. COVID-19: CADD to the rescue |pdf=|usr=}}{{32417181}} gab.com Text COVID-19: CADD to the rescue JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32417181 #FOAvip The recent outbreak of the deadly COVID-19 disease, being caused by the novel coronavirus (SARS-CoV-2), has put the world on red alert as it keeps spreading and recording more fatalities. Research efforts are being carried out to curtail the disease from spreading as it has been declared as of global health emergency. Hence, there is an exigent need to identify and design drugs that are capable of curing the infection and hinder its continual spread across the globe. Herein, a computer-aided drug design tool known as the virtual screening method was used to screen a database of 44 million compounds to find compounds that have the potential to inhibit the surface glycoprotein responsible for virus entry and binding. The consensus scoring approach selected three compounds with promising physicochemical properties and favorable molecular interactions with the target protein. These selected compounds can undergo lead optimization to be further developed as drugs that can be used in treating the COVID-19 disease. Twit Text FOAVip COVID-19: CADD to the rescue ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32417181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32417181 #FOAvip English Wikipedia <ref>{{Cite pmid|32417181}}</ref> COVID-19: CADD to the rescue #MMPMID32417181 Onawole AT; Sulaiman KO; Kolapo TU; Akinde FO; Adegoke RO Virus Res 2020[Aug]; 285 (ä): 198022 PMID32417181show ga The recent outbreak of the deadly COVID-19 disease, being caused by the novel coronavirus (SARS-CoV-2), has put the world on red alert as it keeps spreading and recording more fatalities. Research efforts are being carried out to curtail the disease from spreading as it has been declared as of global health emergency. Hence, there is an exigent need to identify and design drugs that are capable of curing the infection and hinder its continual spread across the globe. Herein, a computer-aided drug design tool known as the virtual screening method was used to screen a database of 44 million compounds to find compounds that have the potential to inhibit the surface glycoprotein responsible for virus entry and binding. The consensus scoring approach selected three compounds with promising physicochemical properties and favorable molecular interactions with the target protein. These selected compounds can undergo lead optimization to be further developed as drugs that can be used in treating the COVID-19 disease. |*Drug Design[MESH] |Antiviral Agents/*chemistry/metabolism/*pharmacology/toxicity[MESH] |Betacoronavirus/*drug effects/physiology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drug Evaluation, Preclinical/methods[MESH] |Humans[MESH] |Ligands[MESH] |Machine Learning[MESH] |Models, Molecular[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Protein Binding[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*antagonists & inhibitors/chemistry/metabolism[MESH]COVID-19: CADD to the rescue (epmc).pdf DeepDyve Pubget Overpricing