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10.2174/1568026620999200517043137 http://scihub22266oqcxt.onion/10.2174/1568026620999200517043137 32416679!ä!32416679 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Top+Med+Chem 2020 ; 20 (16): 1423-1433 Nephropedia Template TP {{tp|p=32416679|t=2020. Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery |pdf=|usr=}}{{32416679}} gab.com Text Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery JO: Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32416679 #FOAvip Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARS-CoV-2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit the spread of SARS-CoV-2 and morbidity and mortality due to the COVID-19 pandemic. Twit Text FOAVip Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery ????Curr Top Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32416679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32416679 #FOAvip English Wikipedia <ref>{{Cite pmid|32416679}}</ref> Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery #MMPMID32416679 Sternberg A; McKee DL; Naujokat C Curr Top Med Chem 2020[]; 20 (16): 1423-1433 PMID32416679show ga Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARS-CoV-2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit the spread of SARS-CoV-2 and morbidity and mortality due to the COVID-19 pandemic. |*Drug Repositioning[MESH] |*Virus Internalization[MESH] |*Virus Replication[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Coronavirus RNA-Dependent RNA Polymerase[MESH] |Cysteine Endopeptidases[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |RNA-Dependent RNA Polymerase/antagonists & inhibitors[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors[MESH]Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery (epmc).pdf DeepDyve Pubget Overpricing