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10.1007/s11547-020-01216-9

http://scihub22266oqcxt.onion/10.1007/s11547-020-01216-9
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32415472!7227177!32415472
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suck abstract from ncbi


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pmid32415472      Radiol+Med 2021 ; 126 (1): 142-146
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  • Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice #MMPMID32415472
  • Barra S; Guarnieri A; di Monale E Bastia MB; Marcenaro M; Tornari E; Belgioia L; Magrini SM; Ricardi U; Corvo R
  • Radiol Med 2021[Jan]; 126 (1): 142-146 PMID32415472show ga
  • INTRODUCTION: To evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option in emergency health conditions. MATERIALS AND METHODS: From April 2013 to September 2015, 28 patients with low-risk prostate cancer were prospectively enrolled. The SBRT prescribed dose was 36.25 Gy in 5 fractions, twice a week. Primary endpoints were acute and late toxicity. Secondary endpoints were biochemical recurrence free survival (bRFS) and overall survival. RESULTS: Median follow-up was 65.5 months (range 52-81). No acute G3 or G4 toxicity was recorded. Acute G1 or G2 genitourinary (GU) toxicity occurred in 43% and acute G1-G2 gastrointestinal (GI) toxicity in 14%. Late G1 and G3 GU toxicity in 18% and 3.5%, respectively. The G3 toxicity was not directly attributable to radiotherapy. Late G1 GI toxicity occurred in 18%. 5yy bRFS was 96.5% (95% CI 82.3-99.4%). CONCLUSIONS: Stereotactic body radiotherapy for early prostate cancer reported safe toxicity profile and a good clinical outcome at the median follow-up of 5 years. It may be an useful option if radiotherapy is required in emergency medical conditions.
  • |*Radiosurgery[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Cone-Beam Computed Tomography[MESH]
  • |Dose Fractionation, Radiation[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prospective Studies[MESH]
  • |Prostatic Neoplasms/*radiotherapy[MESH]
  • |SARS-CoV-2[MESH]


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