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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Transplant 2020 ; 20 (10): 2876-2882 Nephropedia Template TP
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First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study #MMPMID32412159
Tschopp J; L'Huillier AG; Mombelli M; Mueller NJ; Khanna N; Garzoni C; Meloni D; Papadimitriou-Olivgeris M; Neofytos D; Hirsch HH; Schuurmans MM; Muller T; Berney T; Steiger J; Pascual M; Manuel O; van Delden C
Am J Transplant 2020[Oct]; 20 (10): 2876-2882 PMID32412159show ga
Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data of SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety-five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow-up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.