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10.1111/ijcp.13535 http://scihub22266oqcxt.onion/10.1111/ijcp.13535 32412158!7261995!32412158     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Pract 2020 ; 74 (9): e13535 Nephropedia Template TP {{tp|p=32412158|t=2020. Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2/COVID-19 |pdf=|usr=}}{{32412158}} gab.com Text Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2/COVID-19 JO: Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32412158 #FOAvip The ongoing pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2, also known as COVID-19) has led to unprecedented challenges for the global healthcare system. This novel coronavirus disease phenotype ranges from asymptomatic carriage to fulminant cytokine storm with respiratory failure, polyorgan dysfunction and death. Severe disease is characterised by exuberant inflammation resulting from high circulating cytokines such as interleukin-6 and tumour necrosis factor. These inflammatory mediators are responsible for the detrimental effects on the immune, hematologic, respiratory, renal, gastrointestinal and other body systems. In addition to inhibition of viral replication, blunting this inflammatory response before overt cytokine storm is important to improve outcomes. Although there are upcoming promising agents such as remdesivir and convalescent plasma, inexpensive, safe and widely available adjunct treatments to ameliorate disease burden would be welcome. Two potential anti-inflammatory agents include indomethacin, which has been shown in experimental models to decrease canine coronavirus levels in dogs and exhibit antiviral activity against several other viruses and the polyphenol, resveratrol, a potent antioxidant that has shown antiviral activity against several viruses. Twit Text FOAVip Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2/COVID-19 ????Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32412158 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32412158 #FOAvip English Wikipedia <ref>{{Cite pmid|32412158}}</ref> Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2/COVID-19 #MMPMID32412158 Marinella MA Int J Clin Pract 2020[Sep]; 74 (9): e13535 PMID32412158show ga The ongoing pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2, also known as COVID-19) has led to unprecedented challenges for the global healthcare system. This novel coronavirus disease phenotype ranges from asymptomatic carriage to fulminant cytokine storm with respiratory failure, polyorgan dysfunction and death. Severe disease is characterised by exuberant inflammation resulting from high circulating cytokines such as interleukin-6 and tumour necrosis factor. These inflammatory mediators are responsible for the detrimental effects on the immune, hematologic, respiratory, renal, gastrointestinal and other body systems. In addition to inhibition of viral replication, blunting this inflammatory response before overt cytokine storm is important to improve outcomes. Although there are upcoming promising agents such as remdesivir and convalescent plasma, inexpensive, safe and widely available adjunct treatments to ameliorate disease burden would be welcome. Two potential anti-inflammatory agents include indomethacin, which has been shown in experimental models to decrease canine coronavirus levels in dogs and exhibit antiviral activity against several other viruses and the polyphenol, resveratrol, a potent antioxidant that has shown antiviral activity against several viruses. |*Betacoronavirus[MESH] |Animals[MESH] |Antioxidants/*therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy[MESH] |Cyclooxygenase Inhibitors/*therapeutic use[MESH] |Cytokines[MESH] |Dogs[MESH] |Humans[MESH] |Indomethacin/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Resveratrol/*therapeutic use[MESH] |SARS-CoV-2[MESH]Indomethacin and resveratrol as potential treatment adjuncts for SARS(epmc).pdf DeepDyve Pubget Overpricing