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10.1177/1470320320926899

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32408793!7231906!32408793
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suck abstract from ncbi


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pmid32408793      J+Renin+Angiotensin+Aldosterone+Syst 2020 ; 21 (2): 1470320320926899
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  • Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression #MMPMID32408793
  • Pranata R; Lim MA; Huang I; Raharjo SB; Lukito AA
  • J Renin Angiotensin Aldosterone Syst 2020[Apr]; 21 (2): 1470320320926899 PMID32408793show ga
  • OBJECTIVE: To investigate the association between hypertension and outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia. METHODS: We performed a systematic literature search from several databases on studies that assess hypertension and outcome in COVID-19. Composite of poor outcome, comprising of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care unit (ICU) care and disease progression were the outcomes of interest. RESULTS: A total of 6560 patients were pooled from 30 studies. Hypertension was associated with increased composite poor outcome (risk ratio (RR) 2.11 (95% confidence interval (CI) 1.85, 2.40), p < 0.001; I(2), 44%) and its sub-group, including mortality (RR 2.21 (1.74, 2.81), p < 0.001; I(2), 66%), severe COVID-19 (RR 2.04 (1.69, 2.47), p < 0.001; I(2) 31%), ARDS (RR 1.64 (1.11, 2.43), p = 0.01; I(2),0%, p = 0.35), ICU care (RR 2.11 (1.34, 3.33), p = 0.001; I(2) 18%, p = 0.30), and disease progression (RR 3.01 (1.51, 5.99), p = 0.002; I(2) 0%, p = 0.55). Meta-regression analysis showed that gender (p = 0.013) was a covariate that affects the association. The association was stronger in studies with a percentage of males < 55% compared to ? 55% (RR 2.32 v. RR 1.79). CONCLUSION: Hypertension was associated with increased composite poor outcome, including mortality, severe COVID-19, ARDS, need for ICU care and disease progression in patients with COVID-19.
  • |*Betacoronavirus[MESH]
  • |*Coronavirus Infections/complications/mortality/physiopathology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/complications/mortality/physiopathology[MESH]
  • |COVID-19[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hypertension/*complications[MESH]
  • |Intensive Care Units[MESH]
  • |Male[MESH]
  • |Respiratory Distress Syndrome/complications/mortality/physiopathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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