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10.3390/ijms21103426 http://scihub22266oqcxt.onion/10.3390/ijms21103426 32408699!7279430!32408699     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (10): ä Nephropedia Template TP {{tp|p=32408699|t=2020. Essential Oils as Antiviral Agents Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation |pdf=|usr=}}{{32408699}} gab.com Text Essential Oils as Antiviral Agents Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32408699 #FOAvip Essential oils have shown promise as antiviral agents against several pathogenic viruses. In this work we hypothesized that essential oil components may interact with key protein targets of the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A molecular docking analysis was carried out using 171 essential oil components with SARS-CoV-2 main protease (SARS-CoV-2 M(pro)), SARS-CoV-2 endoribonucleoase (SARS-CoV-2 Nsp15/NendoU), SARS-CoV-2 ADP-ribose-1''-phosphatase (SARS-CoV-2 ADRP), SARS-CoV-2 RNA-dependent RNA polymerase (SARS-CoV-2 RdRp), the binding domain of the SARS-CoV-2 spike protein (SARS-CoV-2 rS), and human angiotensin-converting enzyme (hACE2). The compound with the best normalized docking score to SARS-CoV-2 M(pro) was the sesquiterpene hydrocarbon (E)-beta-farnesene. The best docking ligands for SARS-CoV Nsp15/NendoU were (E,E)-alpha-farnesene, (E)-beta-farnesene, and (E,E)-farnesol. (E,E)-Farnesol showed the most exothermic docking to SARS-CoV-2 ADRP. Unfortunately, the docking energies of (E,E)-alpha-farnesene, (E)-beta-farnesene, and (E,E)-farnesol with SARS-CoV-2 targets were relatively weak compared to docking energies with other proteins and are, therefore, unlikely to interact with the virus targets. However, essential oil components may act synergistically, essential oils may potentiate other antiviral agents, or they may provide some relief of COVID-19 symptoms. Twit Text FOAVip Essential Oils as Antiviral Agents Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32408699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32408699 #FOAvip English Wikipedia <ref>{{Cite pmid|32408699}}</ref> Essential Oils as Antiviral Agents Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation #MMPMID32408699 Silva JKRD; Figueiredo PLB; Byler KG; Setzer WN Int J Mol Sci 2020[May]; 21 (10): ä PMID32408699show ga Essential oils have shown promise as antiviral agents against several pathogenic viruses. In this work we hypothesized that essential oil components may interact with key protein targets of the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A molecular docking analysis was carried out using 171 essential oil components with SARS-CoV-2 main protease (SARS-CoV-2 M(pro)), SARS-CoV-2 endoribonucleoase (SARS-CoV-2 Nsp15/NendoU), SARS-CoV-2 ADP-ribose-1''-phosphatase (SARS-CoV-2 ADRP), SARS-CoV-2 RNA-dependent RNA polymerase (SARS-CoV-2 RdRp), the binding domain of the SARS-CoV-2 spike protein (SARS-CoV-2 rS), and human angiotensin-converting enzyme (hACE2). The compound with the best normalized docking score to SARS-CoV-2 M(pro) was the sesquiterpene hydrocarbon (E)-beta-farnesene. The best docking ligands for SARS-CoV Nsp15/NendoU were (E,E)-alpha-farnesene, (E)-beta-farnesene, and (E,E)-farnesol. (E,E)-Farnesol showed the most exothermic docking to SARS-CoV-2 ADRP. Unfortunately, the docking energies of (E,E)-alpha-farnesene, (E)-beta-farnesene, and (E,E)-farnesol with SARS-CoV-2 targets were relatively weak compared to docking energies with other proteins and are, therefore, unlikely to interact with the virus targets. However, essential oil components may act synergistically, essential oils may potentiate other antiviral agents, or they may provide some relief of COVID-19 symptoms. |Angiotensin-Converting Enzyme 2[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Betacoronavirus/drug effects[MESH] |COVID-19[MESH] |Computer Simulation[MESH] |Coronavirus Infections/*therapy[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Oils, Volatile/pharmacology/*therapeutic use[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*therapy[MESH] |Protein Binding/drug effects[MESH] |SARS-CoV-2[MESH]Essential Oils as Antiviral Agents Potential of Essential Oils to Tre(epmc).pdf DeepDyve Pubget Overpricing