Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41586-020-2342-5 http://scihub22266oqcxt.onion/10.1038/s41586-020-2342-5 32408338!7394720!32408338     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 583 (7818): 834-838 Nephropedia Template TP {{tp|p=32408338|t=2020. Pathogenesis and transmission of SARS-CoV-2 in golden hamsters |pdf=|usr=}}{{32408338}} gab.com Text Pathogenesis and transmission of SARS-CoV-2 in golden hamsters JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32408338 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies(1,2). A suitable small animal model is needed to support the development of vaccines and therapies. Here we report the pathogenesis and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters (Mesocricetus auratus). Immunohistochemistry assay demonstrated the presence of viral antigens in nasal mucosa, bronchial epithelial cells and areas of lung consolidation on days 2 and 5 after inoculation with SARS-CoV-2, followed by rapid viral clearance and pneumocyte hyperplasia at 7 days after inoculation. We also found viral antigens in epithelial cells of the duodenum, and detected viral RNA in faeces. Notably, SARS-CoV-2 was transmitted efficiently from inoculated hamsters to naive hamsters by direct contact and via aerosols. Transmission via fomites in soiled cages was not as efficient. Although viral RNA was continuously detected in the nasal washes of inoculated hamsters for 14 days, the communicable period was short and correlated with the detection of infectious virus but not viral RNA. Inoculated and naturally infected hamsters showed apparent weight loss on days 6-7 post-inoculation or post-contact; all hamsters returned to their original weight within 14 days and developed neutralizing antibodies. Our results suggest that features associated with SARS-CoV-2 infection in golden hamsters resemble those found in humans with mild SARS-CoV-2 infections. Twit Text FOAVip Pathogenesis and transmission of SARS-CoV-2 in golden hamsters ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32408338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32408338 #FOAvip English Wikipedia <ref>{{Cite pmid|32408338}}</ref> Pathogenesis and transmission of SARS-CoV-2 in golden hamsters #MMPMID32408338 Sia SF; Yan LM; Chin AWH; Fung K; Choy KT; Wong AYL; Kaewpreedee P; Perera RAPM; Poon LLM; Nicholls JM; Peiris M; Yen HL Nature 2020[Jul]; 583 (7818): 834-838 PMID32408338show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus with high nucleotide identity to SARS-CoV and to SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world and had a global effect on healthcare systems and economies(1,2). A suitable small animal model is needed to support the development of vaccines and therapies. Here we report the pathogenesis and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters (Mesocricetus auratus). Immunohistochemistry assay demonstrated the presence of viral antigens in nasal mucosa, bronchial epithelial cells and areas of lung consolidation on days 2 and 5 after inoculation with SARS-CoV-2, followed by rapid viral clearance and pneumocyte hyperplasia at 7 days after inoculation. We also found viral antigens in epithelial cells of the duodenum, and detected viral RNA in faeces. Notably, SARS-CoV-2 was transmitted efficiently from inoculated hamsters to naive hamsters by direct contact and via aerosols. Transmission via fomites in soiled cages was not as efficient. Although viral RNA was continuously detected in the nasal washes of inoculated hamsters for 14 days, the communicable period was short and correlated with the detection of infectious virus but not viral RNA. Inoculated and naturally infected hamsters showed apparent weight loss on days 6-7 post-inoculation or post-contact; all hamsters returned to their original weight within 14 days and developed neutralizing antibodies. Our results suggest that features associated with SARS-CoV-2 infection in golden hamsters resemble those found in humans with mild SARS-CoV-2 infections. |*Disease Models, Animal[MESH] |Aerosols[MESH] |Alveolar Epithelial Cells/pathology/virology[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Antigens, Viral/immunology/isolation & purification/metabolism[MESH] |Betacoronavirus/immunology/isolation & purification/metabolism/*pathogenicity[MESH] |Bronchi/pathology/virology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*transmission/*virology[MESH] |Duodenum/virology[MESH] |Fomites/virology[MESH] |Housing, Animal[MESH] |Kidney/virology[MESH] |Lung/*pathology/*virology[MESH] |Male[MESH] |Mesocricetus/immunology/*virology[MESH] |Nasal Mucosa/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/*transmission/*virology[MESH] |RNA, Viral/analysis[MESH] |SARS-CoV-2[MESH] |Viral Load[MESH]Pathogenesis and transmission of SARS-CoV-2 in golden hamsters (epmc).pdf DeepDyve Pubget Overpricing