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10.1016/j.cbpa.2020.04.002 http://scihub22266oqcxt.onion/10.1016/j.cbpa.2020.04.002 32408221!7483230!32408221     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Chem+Biol 2020 ; 57 (ä): 27-33 Nephropedia Template TP {{tp|p=32408221|t=2020. Advances in imaging of understudied ions in signaling: A focus on magnesium |pdf=|usr=}}{{32408221}} gab.com Text Advances in imaging of understudied ions in signaling: A focus on magnesium JO: Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=32408221 #FOAvip The study of metal ions in the context of cell signaling has historically focused mainly on Ca(2+), the second messenger par excellence. But recent studies support an emerging paradigm in which other metals, including magnesium and d-block metals, play a role in signal transduction as well. Armed with the right indicators, fluorescence microscopy offers a unique combination of spatial and temporal resolution perfectly suited to reveal metal transients in real time, while also helping identify possible sources of ion mobilization and molecular targets. With a focus on Mg(2+), we highlight recent advancements in the development of molecular indicators and imaging strategies for the study of metal ions in signaling. We discuss remaining conceptual and technical challenges in the field, and we illustrate through the case of Mg(2+) how the study of nontraditional ions in signaling is inspiring technological developments applicable more broadly to the study of metals in biology. Twit Text FOAVip Advances in imaging of understudied ions in signaling: A focus on magnesium ????Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=32408221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32408221 #FOAvip English Wikipedia <ref>{{Cite pmid|32408221}}</ref> Advances in imaging of understudied ions in signaling: A focus on magnesium #MMPMID32408221 Lazarou TS; Buccella D Curr Opin Chem Biol 2020[Aug]; 57 (ä): 27-33 PMID32408221show ga The study of metal ions in the context of cell signaling has historically focused mainly on Ca(2+), the second messenger par excellence. But recent studies support an emerging paradigm in which other metals, including magnesium and d-block metals, play a role in signal transduction as well. Armed with the right indicators, fluorescence microscopy offers a unique combination of spatial and temporal resolution perfectly suited to reveal metal transients in real time, while also helping identify possible sources of ion mobilization and molecular targets. With a focus on Mg(2+), we highlight recent advancements in the development of molecular indicators and imaging strategies for the study of metal ions in signaling. We discuss remaining conceptual and technical challenges in the field, and we illustrate through the case of Mg(2+) how the study of nontraditional ions in signaling is inspiring technological developments applicable more broadly to the study of metals in biology. |Animals[MESH] |Humans[MESH] |Ions/analysis/metabolism[MESH] |Magnesium/analysis/*metabolism[MESH] |Microscopy, Fluorescence/methods[MESH] |Models, Molecular[MESH] |Molecular Imaging/*methods[MESH] |Optical Imaging/*methods[MESH]Advances in imaging of understudied ions in signaling: A focus on magn(epmc).pdf DeepDyve Pubget Overpricing