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10.1016/j.dsx.2020.04.044 http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.04.044 32408118!7200339!32408118     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+Syndr 2020 ; 14 (4): 535-545 Nephropedia Template TP {{tp|p=32408118|t=2020. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis |pdf=|usr=}}{{32408118}} gab.com Text Is diabetes mellitus associated with mortality and severity of COVID-19 A meta-analysis JO: Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32408118 #FOAvip BACKGROUND: Many studies on COVID-19 have reported diabetes to be associated with severe disease and mortality, however, the data is conflicting. The objectives of this meta-analysis were to explore the relationship between diabetes and COVID-19 mortality and severity, and to determine the prevalence of diabetes in patients with COVID-19. METHODS: We searched the PubMed for case-control studies in English, published between Jan 1 and Apr 22, 2020, that had data on diabetes in patients with COVID-19. The frequency of diabetes was compared between patients with and without the composite endpoint of mortality or severity. Random effects model was used with odds ratio as the effect size. We also determined the pooled prevalence of diabetes in patients with COVID-19. Heterogeneity and publication bias were taken care by meta-regression, sub-group analyses, and trim and fill methods. RESULTS: We included 33 studies (16,003 patients) and found diabetes to be significantly associated with mortality of COVID-19 with a pooled odds ratio of 1.90 (95% CI: 1.37-2.64; p < 0.01). Diabetes was also associated with severe COVID-19 with a pooled odds ratio of 2.75 (95% CI: 2.09-3.62; p < 0.01). The combined corrected pooled odds ratio of mortality or severity was 2.16 (95% CI: 1.74-2.68; p < 0.01). The pooled prevalence of diabetes in patients with COVID-19 was 9.8% (95% CI: 8.7%-10.9%) (after adjusting for heterogeneity). CONCLUSIONS: Diabetes in patients with COVID-19 is associated with a two-fold increase in mortality as well as severity of COVID-19, as compared to non-diabetics. Further studies on the pathogenic mechanisms and therapeutic implications need to be done. Twit Text FOAVip Is diabetes mellitus associated with mortality and severity of COVID-19 A meta-analysis ????Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32408118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32408118 #FOAvip English Wikipedia <ref>{{Cite pmid|32408118}}</ref> Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis #MMPMID32408118 Kumar A; Arora A; Sharma P; Anikhindi SA; Bansal N; Singla V; Khare S; Srivastava A Diabetes Metab Syndr 2020[Jul]; 14 (4): 535-545 PMID32408118show ga BACKGROUND: Many studies on COVID-19 have reported diabetes to be associated with severe disease and mortality, however, the data is conflicting. The objectives of this meta-analysis were to explore the relationship between diabetes and COVID-19 mortality and severity, and to determine the prevalence of diabetes in patients with COVID-19. METHODS: We searched the PubMed for case-control studies in English, published between Jan 1 and Apr 22, 2020, that had data on diabetes in patients with COVID-19. The frequency of diabetes was compared between patients with and without the composite endpoint of mortality or severity. Random effects model was used with odds ratio as the effect size. We also determined the pooled prevalence of diabetes in patients with COVID-19. Heterogeneity and publication bias were taken care by meta-regression, sub-group analyses, and trim and fill methods. RESULTS: We included 33 studies (16,003 patients) and found diabetes to be significantly associated with mortality of COVID-19 with a pooled odds ratio of 1.90 (95% CI: 1.37-2.64; p < 0.01). Diabetes was also associated with severe COVID-19 with a pooled odds ratio of 2.75 (95% CI: 2.09-3.62; p < 0.01). The combined corrected pooled odds ratio of mortality or severity was 2.16 (95% CI: 1.74-2.68; p < 0.01). The pooled prevalence of diabetes in patients with COVID-19 was 9.8% (95% CI: 8.7%-10.9%) (after adjusting for heterogeneity). CONCLUSIONS: Diabetes in patients with COVID-19 is associated with a two-fold increase in mortality as well as severity of COVID-19, as compared to non-diabetics. Further studies on the pathogenic mechanisms and therapeutic implications need to be done. |*Severity of Illness Index[MESH] |Betacoronavirus/*pathogenicity[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/epidemiology/*mortality/virology[MESH] |Diabetes Mellitus/epidemiology/*mortality/virology[MESH] |Global Health[MESH] |Humans[MESH] |Incidence[MESH] |Pandemics[MESH] |Pneumonia, Viral/epidemiology/*mortality/virology[MESH] |SARS-CoV-2[MESH]Is diabetes mellitus associated with mortality and severity of COVID-1(epmc).pdf DeepDyve Pubget Overpricing