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10.1016/j.mehy.2020.109815

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109815
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suck abstract from ncbi


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pmid32408070      Med+Hypotheses 2020 ; 142 (ä): 109815
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  • Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today s battle against COVID-19? #MMPMID32408070
  • Derwand R; Scholz M
  • Med Hypotheses 2020[Sep]; 142 (ä): 109815 PMID32408070show ga
  • Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mortality. CQ and HCQ (CQ/HCQ) inhibit pH-dependent steps of SARS-CoV-2 replication by increasing pH in intracellular vesicles and interfere with virus particle delivery into host cells. Besides direct antiviral effects, CQ/HCQ specifically target extracellular zinc to intracellular lysosomes where it interferes with RNA-dependent RNA polymerase activity and coronavirus replication. As zinc deficiency frequently occurs in elderly patients and in those with cardiovascular disease, chronic pulmonary disease, or diabetes, we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials.
  • |*Dietary Supplements[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Chloroquine/*administration & dosage[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Synergism[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Hydroxychloroquine/*administration & dosage[MESH]
  • |Length of Stay[MESH]
  • |Lysosomes/drug effects/metabolism[MESH]
  • |Male[MESH]
  • |Models, Theoretical[MESH]
  • |Pandemics[MESH]
  • |Patient Safety[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |SARS-CoV-2[MESH]


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