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10.1016/j.chom.2020.04.017 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.04.017 32407669!7196896!32407669     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 27 (6): 883-890.e2 Nephropedia Template TP {{tp|p=32407669|t=2020. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients |pdf=|usr=}}{{32407669}} gab.com Text Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32407669 #FOAvip The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection have posed a severe threat to global public health. It is unclear how the human immune system responds to this infection. Here, we used metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of eight COVID-19 cases. The expression of proinflammatory genes, especially chemokines, was markedly elevated in COVID-19 cases compared to community-acquired pneumonia patients and healthy controls, suggesting that SARS-CoV-2 infection causes hypercytokinemia. Compared to SARS-CoV, which is thought to induce inadequate interferon (IFN) responses, SARS-CoV-2 robustly triggered expression of numerous IFN-stimulated genes (ISGs). These ISGs exhibit immunopathogenic potential, with overrepresentation of genes involved in inflammation. The transcriptome data was also used to estimate immune cell populations, revealing increases in activated dendritic cells and neutrophils. Collectively, these host responses to SARS-CoV-2 infection could further our understanding of disease pathogenesis and point toward antiviral strategies. Twit Text FOAVip Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32407669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32407669 #FOAvip English Wikipedia <ref>{{Cite pmid|32407669}}</ref> Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients #MMPMID32407669 Zhou Z; Ren L; Zhang L; Zhong J; Xiao Y; Jia Z; Guo L; Yang J; Wang C; Jiang S; Yang D; Zhang G; Li H; Chen F; Xu Y; Chen M; Gao Z; Yang J; Dong J; Liu B; Zhang X; Wang W; He K; Jin Q; Li M; Wang J Cell Host Microbe 2020[Jun]; 27 (6): 883-890.e2 PMID32407669show ga The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection have posed a severe threat to global public health. It is unclear how the human immune system responds to this infection. Here, we used metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of eight COVID-19 cases. The expression of proinflammatory genes, especially chemokines, was markedly elevated in COVID-19 cases compared to community-acquired pneumonia patients and healthy controls, suggesting that SARS-CoV-2 infection causes hypercytokinemia. Compared to SARS-CoV, which is thought to induce inadequate interferon (IFN) responses, SARS-CoV-2 robustly triggered expression of numerous IFN-stimulated genes (ISGs). These ISGs exhibit immunopathogenic potential, with overrepresentation of genes involved in inflammation. The transcriptome data was also used to estimate immune cell populations, revealing increases in activated dendritic cells and neutrophils. Collectively, these host responses to SARS-CoV-2 infection could further our understanding of disease pathogenesis and point toward antiviral strategies. |*Immunity, Innate[MESH] |Bronchoalveolar Lavage Fluid/cytology/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/pathology[MESH] |Cytokine Release Syndrome[MESH] |Cytokines/analysis[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/pathology[MESH]Heightened Innate Immune Responses in the Respiratory Tract of COVID-1(epmc).pdf DeepDyve Pubget Overpricing