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10.1093/cid/ciaa577

http://scihub22266oqcxt.onion/10.1093/cid/ciaa577
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32407466!7239202!32407466
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suck abstract from ncbi


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pmid32407466      Clin+Infect+Dis 2020 ; 71 (16): 2272-2275
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  • An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019 #MMPMID32407466
  • Bordoni V; Sacchi A; Cimini E; Notari S; Grassi G; Tartaglia E; Casetti R; Giancola ML; Bevilacqua N; Maeurer M; Zumla A; Locatelli F; De Benedetti F; Palmieri F; Marchioni L; Capobianchi MR; D'Offizi G; Petrosillo N; Antinori A; Nicastri E; Ippolito G; Agrati C
  • Clin Infect Dis 2020[Nov]; 71 (16): 2272-2275 PMID32407466show ga
  • Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
  • |Aged[MESH]
  • |COVID-19/blood/*immunology[MESH]
  • |Cytokines/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation/*blood/complications/immunology[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Italy[MESH]
  • |Killer Cells, Natural/*immunology[MESH]
  • |Lymphocyte Activation/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Perforin/*immunology[MESH]
  • |SARS-CoV-2[MESH]


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