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10.1002/jmv.26003

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suck abstract from ncbi


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pmid32406952      J+Med+Virol 2020 ; 92 (10): 2152-2158
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  • Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity #MMPMID32406952
  • Huang J; Cheng A; Kumar R; Fang Y; Chen G; Zhu Y; Lin S
  • J Med Virol 2020[Oct]; 92 (10): 2152-2158 PMID32406952show ga
  • The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. Most of the literature show that the elevated liver enzymes in COVID-19 are of little clinical significance. Lower albumin level is seen in severe COVID-19 and is not parallel to the changes in alanine aminotransferase and aspartate aminotransferase levels. We aimed to explore the impact of hypoalbuminemia in COVID-19. This retrospective cohort study included adult patients with confirmed COVID-19. The relationship between hypoalbuminemia and death was studied using binary logistic analysis. A total of 299 adult patients were included, 160 (53.5%) were males and the average age was 53.4 +/- 16.7 years. The median time from the onset of illness to admission was 3 days (interquartile ranges, 2-5). Approximately one-third of the patients had comorbidities. Hypoalbuminemia (<35 g/L) was found in 106 (35.5%) patients. The difference in albumin was considerable between survivors and non-survivors (37.6 +/- 6.2 vs 30.5 +/- 4.0, P < .001). Serum albumin level was inversely correlated to white blood cell (r = -.149, P = .01) and neutrophil to lymphocyte ratio (r = -.298, P < .001). Multivariate analysis showed the presence of comorbidities (OR, 6.816; 95% CI, 1.361-34.133), lymphopenia (OR, 13.130; 95% CI, 1.632-105.658) and hypoalbuminemia (OR, 6.394; 95% CI, 1.315-31.092) were independent predictive factors for mortality. In conclusion, hypoalbuminemia is associated with the outcome of COVID-19. The potential therapeutic value of albumin infusion in COVID-19 should be further explored at the earliest.
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |COVID-19/*diagnosis/physiopathology[MESH]
  • |China[MESH]
  • |Comorbidity[MESH]
  • |Electronic Health Records[MESH]
  • |Female[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hypoalbuminemia/*complications[MESH]
  • |Liver Diseases/blood/complications[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Retrospective Studies[MESH]


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