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10.1016/j.drudis.2020.05.005 http://scihub22266oqcxt.onion/10.1016/j.drudis.2020.05.005 32405248!7217646!32405248     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2020 ; 25 (8): 1298-1306 Nephropedia Template TP {{tp|p=32405248|t=2020. SCHOOL of nature: ligand-independent immunomodulatory peptides |pdf=|usr=}}{{32405248}} gab.com Text SCHOOL of nature: ligand-independent immunomodulatory peptides JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32405248 #FOAvip Groundbreaking studies in protein biophysics have identified the mechanisms of transmembrane signaling at the level of druggable protein-protein interactions (PPIs). This resulted in the development of the signaling chain homooligomerization (SCHOOL) strategy to modulate cell responses using receptor-specific peptides. Inspired by nature, these short peptides use ligand-independent mechanisms of receptor inhibition and demonstrate potent efficacy in vitro and in vivo. The SCHOOL strategy is especially important when receptor ligands are unknown. An example is the triggering receptor expressed on myeloid cells-1 (TREM-1) receptor, an emerging therapeutic target involved in the pathogenesis of most inflammatory diseases. Here, I discuss advances in the field with a focus on TREM-1 inhibitory SCHOOL peptides that offer new hope for a 'magic bullet' cure for cancer, arthritis, sepsis, retinopathy, and other medical challenges. Twit Text FOAVip SCHOOL of nature: ligand-independent immunomodulatory peptides ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32405248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32405248 #FOAvip English Wikipedia <ref>{{Cite pmid|32405248}}</ref> SCHOOL of nature: ligand-independent immunomodulatory peptides #MMPMID32405248 Sigalov AB Drug Discov Today 2020[Aug]; 25 (8): 1298-1306 PMID32405248show ga Groundbreaking studies in protein biophysics have identified the mechanisms of transmembrane signaling at the level of druggable protein-protein interactions (PPIs). This resulted in the development of the signaling chain homooligomerization (SCHOOL) strategy to modulate cell responses using receptor-specific peptides. Inspired by nature, these short peptides use ligand-independent mechanisms of receptor inhibition and demonstrate potent efficacy in vitro and in vivo. The SCHOOL strategy is especially important when receptor ligands are unknown. An example is the triggering receptor expressed on myeloid cells-1 (TREM-1) receptor, an emerging therapeutic target involved in the pathogenesis of most inflammatory diseases. Here, I discuss advances in the field with a focus on TREM-1 inhibitory SCHOOL peptides that offer new hope for a 'magic bullet' cure for cancer, arthritis, sepsis, retinopathy, and other medical challenges. |Animals[MESH] |Arthritis/drug therapy[MESH] |Humans[MESH] |Immunologic Factors/*therapeutic use[MESH] |Ligands[MESH] |Neoplasms/drug therapy[MESH] |Peptides/*therapeutic use[MESH] |Retinal Diseases/drug therapy[MESH] |Sepsis/drug therapy[MESH]SCHOOL of nature: ligand-independent immunomodulatory peptides (epmc).pdf DeepDyve Pubget Overpricing