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10.1016/j.cca.2020.05.019

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.05.019
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32405080!7219428!32405080
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suck abstract from ncbi


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pmid32405080      Clin+Chim+Acta 2020 ; 508 (ä): 110-114
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  • Decreased T cell populations contribute to the increased severity of COVID-19 #MMPMID32405080
  • Liu R; Wang Y; Li J; Han H; Xia Z; Liu F; Wu K; Yang L; Liu X; Zhu C
  • Clin Chim Acta 2020[Sep]; 508 (ä): 110-114 PMID32405080show ga
  • BACKGROUND: We observe changes of the main lymphocyte subsets (CD16(+)CD56?CD19?CD3?CD4?and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. METHODS: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. RESULTS: CD3(+), CD4(+) and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3(+), CD4(+) and CD8(+) T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). CONCLUSIONS: Reduced CD3(+), CD4(+), CD8(+) T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |Biomarkers/analysis[MESH]
  • |CD3 Complex/genetics/immunology[MESH]
  • |CD4 Antigens/genetics/immunology[MESH]
  • |CD8 Antigens/genetics/immunology[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/*diagnosis/immunology/mortality/physiopathology[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*diagnosis/immunology/mortality/physiopathology[MESH]
  • |Diabetes Mellitus/*diagnosis/immunology/mortality/physiopathology[MESH]
  • |Female[MESH]
  • |Gene Expression[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Lung Diseases/*diagnosis/immunology/mortality/physiopathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Patient Selection[MESH]
  • |Pneumonia, Viral/*diagnosis/immunology/mortality/physiopathology[MESH]
  • |Prognosis[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Survival Analysis[MESH]


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