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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Chim+Acta 2020 ; 508 (ä): 110-114 Nephropedia Template TP
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Decreased T cell populations contribute to the increased severity of COVID-19 #MMPMID32405080
Liu R; Wang Y; Li J; Han H; Xia Z; Liu F; Wu K; Yang L; Liu X; Zhu C
Clin Chim Acta 2020[Sep]; 508 (ä): 110-114 PMID32405080show ga
BACKGROUND: We observe changes of the main lymphocyte subsets (CD16(+)CD56?CD19?CD3?CD4?and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. METHODS: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. RESULTS: CD3(+), CD4(+) and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3(+), CD4(+) and CD8(+) T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). CONCLUSIONS: Reduced CD3(+), CD4(+), CD8(+) T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.