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10.1126/sciimmunol.abc3582 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abc3582 32404436!7285829!32404436     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (47): ä Nephropedia Template TP {{tp|p=32404436|t=2020. TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes |pdf=|usr=}}{{32404436}} gab.com Text TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32404436 #FOAvip Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2(+) mature enterocytes in human small intestinal enteroids. Expression of two mucosa-specific serine proteases, TMPRSS2 and TMPRSS4, facilitated SARS-CoV-2 spike fusogenic activity and promoted virus entry into host cells. We also demonstrate that viruses released into the intestinal lumen were inactivated by simulated human colonic fluid, and infectious virus was not recovered from the stool specimens of COVID-19 patients. Our results highlight the intestine as a potential site of SARS-CoV-2 replication, which may contribute to local and systemic illness and overall disease progression. Twit Text FOAVip TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32404436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32404436 #FOAvip English Wikipedia <ref>{{Cite pmid|32404436}}</ref> TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes #MMPMID32404436 Zang R; Gomez Castro MF; McCune BT; Zeng Q; Rothlauf PW; Sonnek NM; Liu Z; Brulois KF; Wang X; Greenberg HB; Diamond MS; Ciorba MA; Whelan SPJ; Ding S Sci Immunol 2020[May]; 5 (47): ä PMID32404436show ga Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2(+) mature enterocytes in human small intestinal enteroids. Expression of two mucosa-specific serine proteases, TMPRSS2 and TMPRSS4, facilitated SARS-CoV-2 spike fusogenic activity and promoted virus entry into host cells. We also demonstrate that viruses released into the intestinal lumen were inactivated by simulated human colonic fluid, and infectious virus was not recovered from the stool specimens of COVID-19 patients. Our results highlight the intestine as a potential site of SARS-CoV-2 replication, which may contribute to local and systemic illness and overall disease progression. |*Virus Internalization[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*physiology[MESH] |Cell Line[MESH] |Duodenum/cytology[MESH] |Enterocytes/pathology/*virology[MESH] |Humans[MESH] |Membrane Proteins/*metabolism[MESH] |Mice[MESH] |Organoids/virology[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Rotavirus/physiology[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/*metabolism[MESH]TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intest(epmc).pdf DeepDyve Pubget Overpricing