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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Probl+Cardiol 2020 ; 45 (8): 100617 Nephropedia Template TP
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Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis #MMPMID32402515
Aggarwal G; Cheruiyot I; Aggarwal S; Wong J; Lippi G; Lavie CJ; Henry BM; Sanchis-Gomar F
Curr Probl Cardiol 2020[Aug]; 45 (8): 100617 PMID32402515show ga
Observational studies have reported an association between underlying cardiovascular diseases (CVD) and worse prognosis in COVID-19 patients, but this still remains unclear. We conducted a meta-analysis of recent studies that reported the association of CVD with worse prognosis and increased mortality in COVID-19 patients. Literature search through PubMed, the Cochrane Library, and Embase was completed by 2 reviewers from November 1, 2019 to April 20, 2020. Inclusion criteria were observational case-control or cohort studies on COVID-19 patients with a history of CVD included, which reported outcomes of COVID-19 infection severity, clearly outlined the definition of "severe disease" and with sample size >10. Data were abstracted independently by 2 authors. Studies were divided into 2 separate cohorts for analysis: severity (severe vs nonsevere) and mortality (nonsurvivors vs survivors). Data was pooled into a meta-analysis to estimate pooled odds ratio (OR) with 95% confidence interval (95% CI) for each outcome. A total of 18 studies (n?=?4858 patients) were included. Sixteen studies were from China, while 2 were from the United States. Pre-existing CVD was associated with a significantly increased risk of a severe form of COVID-19 (OR?=?3.14; 95% CI 2.32-4.24; I(2)?=?0%; Q?=?8.68, P= 0.73) and overall risk of COVID-19 all-cause mortality (OR?=?11.08; 95% CI: 2.59-47.32; I(2)?=?55%; P?=?0.11). However, this study did not find a significant association between previous history of CVD and mortality in severe COVID-19 disease (OR?=?1.72; 95% CI: 0.97-3.06, I(2)?=?0%, P?=?0.46). Pre-existing CVD is associated with worse outcomes among patients with COVID-19. Clinicians and policymakers need to take account of these findings in implementing risk stratification models.