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10.1111/ajt.16000

http://scihub22266oqcxt.onion/10.1111/ajt.16000
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32400087!7272824!32400087
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suck abstract from ncbi


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pmid32400087      Am+J+Transplant 2020 ; 20 (7): 1787-1794
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  • Use of SARS-CoV-2-infected deceased organ donors: Should we always "just say no?" #MMPMID32400087
  • Kates OS; Fisher CE; Rakita RM; Reyes JD; Limaye AP
  • Am J Transplant 2020[Jul]; 20 (7): 1787-1794 PMID32400087show ga
  • In the context of a rapidly evolving pandemic, multiple organizations have released guidelines stating that all organs from potential deceased donors with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection should be deferred, including from otherwise medically eligible donors found to have mild or asymptomatic SARS-CoV-2 discovered on routine donor screening. In this article, we critically examine the available data on the risk of transmission of SARS-CoV-2 through organ transplantation. The isolation of SARS-CoV-2 from nonlung clinical specimens, the detection of SARS-CoV-2 in autopsy specimens, previous experience with the related coronaviruses SARS-CoV and MERS-CoV, and the vast experience with other common RNA respiratory viruses are all addressed. Taken together, these data provide little evidence to suggest the presence of intact transmissible SARS-CoV in organs that can potentially be transplanted, specifically liver and heart. Other considerations including ethical, financial, societal, and logistical concerns are also addressed. We conclude that, for selected patients with high waitlist mortality, transplant programs should consider accepting heart or liver transplants from deceased donors with SARS-CoV-2 infection.
  • |*Tissue Donors[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*prevention & control/*transmission[MESH]
  • |Ethics, Medical[MESH]
  • |Heart Transplantation/adverse effects/trends[MESH]
  • |Heart/virology[MESH]
  • |Humans[MESH]
  • |Liver Transplantation/adverse effects/trends[MESH]
  • |Liver/virology[MESH]
  • |Lung/virology[MESH]
  • |Occupational Exposure[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control/*transmission[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/prevention & control[MESH]
  • |Tissue and Organ Procurement/ethics/*standards/*trends[MESH]


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