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10.1111/ajt.15998

http://scihub22266oqcxt.onion/10.1111/ajt.15998
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32400084!7272871!32400084
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suck abstract from ncbi


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pmid32400084      Am+J+Transplant 2020 ; 20 (10): 2928-2932
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  • SARS-CoV-2 infection in two patients following recent lung transplantation #MMPMID32400084
  • Koczulla RA; Sczepanski B; Koteczki A; Kuhnert S; Hecker M; Askevold I; Schneider C; Michel S; Kneidinger N
  • Am J Transplant 2020[Oct]; 20 (10): 2928-2932 PMID32400084show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has become a global health problem with pandemic character. Lung transplant recipients may be particularly at risk due to the high degree of immunosuppression and the lung being the organ primarily affected by COVID-19. We describe a 16-year-old male and a 64-year-old female recently lung transplanted patients with COVID-19 during inpatient rehabilitation. Both patients were receiving triple immunosuppressive therapy and had no signs of allograft dysfunction. Both patients had close contact with a person who developed COVID-19 and were tested positive for SARS-CoV-2. Subsequently, both patients underwent systematic screening and SARS-CoV-2 was ultimately detected. Although the 16-year-old boy was completely asymptomatic, the 64-year-old woman developed only mild COVID-19. Immunosuppressive therapy was unchanged and no experimental treatment was initiated. No signs of graft involvement or dysfunction were noticed. In conclusion, our report of patients with asymptomatic SARS-CoV-2 infection and mild COVID-19, respectively, may indicate that lung transplant recipients are not per se at risk for severe COVID-19. Further observations and controlled trials are urgently needed to study SARS-CoV-2 infection in lung transplant recipients.
  • |*Lung Transplantation[MESH]
  • |*Transplant Recipients[MESH]
  • |Adolescent[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/drug therapy/transmission[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/drug therapy/transmission[MESH]
  • |Postoperative Period[MESH]
  • |RNA, Viral/analysis[MESH]
  • |SARS-CoV-2[MESH]


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