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10.1007/s00395-020-0795-1

http://scihub22266oqcxt.onion/10.1007/s00395-020-0795-1
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32399655!7214858!32399655
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suck abstract from ncbi


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pmid32399655      Basic+Res+Cardiol 2020 ; 115 (4): 36
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  • Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series #MMPMID32399655
  • Singh S; Chakravarty T; Chen P; Akhmerov A; Falk J; Friedman O; Zaman T; Ebinger JE; Gheorghiu M; Marban L; Marban E; Makkar RR
  • Basic Res Cardiol 2020[May]; 115 (4): 36 PMID32399655show ga
  • There are no definitive therapies for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Therefore, new therapeutic strategies are needed to improve clinical outcomes, particularly in patients with severe disease. This case series explores the safety and effectiveness of intravenous allogeneic cardiosphere-derived cells (CDCs), formulated as CAP-1002, in critically ill patients with confirmed coronavirus disease 2019 (COVID-19). Adverse reactions to CAP-1002, clinical status on the World Health Organization (WHO) ordinal scale, and changes in pro-inflammatory biomarkers and leukocyte counts were analyzed. All patients (n = 6; age range 19-75 years, 1 female) required ventilatory support (invasive mechanical ventilation, n = 5) with PaO(2)/FiO(2) ranging from 69 to 198. No adverse events related to CAP-1002 administration were observed. Four patients (67%) were weaned from respiratory support and discharged from the hospital. One patient remains mechanically ventilated as of April 28th, 2020; all survive. A contemporaneous control group of critically ill COVID-19 patients (n = 34) at our institution showed 18% overall mortality at a similar stage of hospitalization. Ferritin was elevated in all patients at baseline (range of all patients 605.43-2991.52 ng/ml) and decreased in 5/6 patients (range of all patients 252.89-1029.90 ng/ml). Absolute lymphocyte counts were low in 5/6 patients at baseline (range 0.26-0.82 x 10(3)/microl) but had increased in three of these five patients at last follow-up (range 0.23-1.02 x 10(3)/microl). In this series of six critically ill COVID-19 patients, intravenous infusion of CAP-1002 was well tolerated and associated with resolution of critical illness in 4 patients. This series demonstrates the apparent safety of CAP-1002 in COVID-19. While this initial experience is promising, efficacy will need to be further assessed in a randomized controlled trial.
  • |*Cell- and Tissue-Based Therapy[MESH]
  • |*Compassionate Use Trials[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*therapy[MESH]
  • |Critical Illness/therapy[MESH]
  • |Female[MESH]
  • |Ferritins/blood[MESH]
  • |Humans[MESH]
  • |Infusions, Intravenous[MESH]
  • |Los Angeles[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocardium/*cytology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*therapy[MESH]
  • |SARS-CoV-2[MESH]
  • |Stem Cells/*cytology[MESH]


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