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10.1038/s41591-020-0901-9

http://scihub22266oqcxt.onion/10.1038/s41591-020-0901-9
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32398875!ä!32398875

suck abstract from ncbi


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pmid32398875      Nat+Med 2020 ; 26 (6): 842-844
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  • Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 #MMPMID32398875
  • Liao M; Liu Y; Yuan J; Wen Y; Xu G; Zhao J; Cheng L; Li J; Wang X; Wang F; Liu L; Amit I; Zhang S; Zhang Z
  • Nat Med 2020[Jun]; 26 (6): 842-844 PMID32398875show ga
  • Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8(+) T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
  • |*Single-Cell Analysis[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |Bronchoalveolar Lavage Fluid/immunology/virology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology/virology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*immunology/*pathology/virology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*immunology/*pathology/virology[MESH]


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