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10.1158/2159-8290.CD-20-0596

http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-20-0596
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32398243!7416461!32398243
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suck abstract from ncbi


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pmid32398243      Cancer+Discov 2020 ; 10 (8): 1121-1128
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  • Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers #MMPMID32398243
  • Luo J; Rizvi H; Egger JV; Preeshagul IR; Wolchok JD; Hellmann MD
  • Cancer Discov 2020[Aug]; 10 (8): 1121-1128 PMID32398243show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has led to dramatic changes in oncology practice. It is currently unknown whether programmed death 1 (PD-1) blockade therapy affects severity of illness from COVID-19 in patients with cancer. To address this uncertainty, we examined consecutive patients with lung cancers who were diagnosed with COVID-19 and examined severity on the basis of no or prior receipt of PD-1 blockade. Overall, the severity of COVID-19 in patients with lung cancer was high, including need for hospitalization in more than half of patients and death in nearly a quarter. Prior PD-1 blockade was, as expected, associated with smoking status. After adjustment for smoking status, PD-1 blockade exposure was not associated with increased risk of severity of COVID-19. PD-1 blockade does not appear to affect the severity of COVID-19 in patients with lung cancers. SIGNIFICANCE: A key question in oncology practice amidst the COVID-19 pandemic is whether PD-1 blockade therapy affects COVID-19 severity. Our analysis of patients with lung cancers supports the safety of PD-1 blockade treatment to achieve optimal cancer outcomes.This article is highlighted in the In This Issue feature, p. 1079.
  • |*Coronavirus[MESH]
  • |*Coronavirus Infections[MESH]
  • |*Lung Neoplasms[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Humans[MESH]
  • |Programmed Cell Death 1 Receptor[MESH]


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