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10.1080/07391102.2020.1767211

http://scihub22266oqcxt.onion/10.1080/07391102.2020.1767211
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suck abstract from ncbi


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pmid32397951      J+Biomol+Struct+Dyn 2021 ; 39 (10): 3780-3786
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  • The expression level of angiotensin-converting enzyme 2 determines the severity of COVID-19: lung and heart tissue as targets #MMPMID32397951
  • Babadaei MMN; Hasan A; Bloukh SH; Edis Z; Sharifi M; Kachooei E; Falahati M
  • J Biomol Struct Dyn 2021[Jul]; 39 (10): 3780-3786 PMID32397951show ga
  • Researchers have reported some useful information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to CoV disease 2019 (COVID-19). Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients. Also, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. It has been well-documented that the surface of host cells is covered by some receptors, known as angiotensin-converting enzyme 2 (ACE2), which mediates the binding and entry of CoV. After entering, the viral RNA interrupts the cell proliferation system to activate self-proliferation. However, having all the information about the outbreakof the SARS-COV-2, it is not still clear which factors determine the severity of lung and heart function impairment induced by COVID-19. A major step in exploring SARS-COV-2 pathogenesis is to determine the distribution of ACE2 in different tissues . In this review, the structure and origin of CoV, the role of ACE2 as a receptor of SARS-COV-2 on the surface of host cells, and the ACE2 distribution in different tissues with a focus on lung and cardiovascular system have been discussed. It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. In conclusion, this review may provide useful information in developing some promising strategies to end up with a worldwide COVID-19 pandemic.Communicated by Ramaswamy H. Sarma.
  • |*COVID-19/diagnosis[MESH]
  • |Angiotensin-Converting Enzyme 2/*genetics[MESH]
  • |Heart[MESH]
  • |Humans[MESH]
  • |Lung[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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