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10.1038/s41586-020-2324-7 http://scihub22266oqcxt.onion/10.1038/s41586-020-2324-7 32396922!7486227!32396922     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 585 (7824): 268-272 Nephropedia Template TP {{tp|p=32396922|t=2020. Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |pdf=|usr=}}{{32396922}} gab.com Text Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32396922 #FOAvip An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 2019(1,2). Following an unprecedented global spread(3), the World Health Organization declared COVID-19 a pandemic on 11 March 2020. Although data on COVID-19 in humans are emerging at a steady pace, some aspects of the pathogenesis of SARS-CoV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection is possible. Here we show that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days. Pulmonary infiltrates, which are a hallmark of COVID-19 in humans, were visible in lung radiographs. We detected high viral loads in swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding. Together, the rhesus macaque recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease, and aid in the development and testing of medical countermeasures. Twit Text FOAVip Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32396922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32396922 #FOAvip English Wikipedia <ref>{{Cite pmid|32396922}}</ref> Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 #MMPMID32396922 Munster VJ; Feldmann F; Williamson BN; van Doremalen N; Perez-Perez L; Schulz J; Meade-White K; Okumura A; Callison J; Brumbaugh B; Avanzato VA; Rosenke R; Hanley PW; Saturday G; Scott D; Fischer ER; de Wit E Nature 2020[Sep]; 585 (7824): 268-272 PMID32396922show ga An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 2019(1,2). Following an unprecedented global spread(3), the World Health Organization declared COVID-19 a pandemic on 11 March 2020. Although data on COVID-19 in humans are emerging at a steady pace, some aspects of the pathogenesis of SARS-CoV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection is possible. Here we show that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days. Pulmonary infiltrates, which are a hallmark of COVID-19 in humans, were visible in lung radiographs. We detected high viral loads in swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding. Together, the rhesus macaque recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease, and aid in the development and testing of medical countermeasures. |*Disease Models, Animal[MESH] |Animals[MESH] |Betacoronavirus/*pathogenicity[MESH] |Body Fluids/virology[MESH] |Bronchoalveolar Lavage[MESH] |COVID-19[MESH] |Coronavirus Infections/complications/*pathology/*physiopathology/virology[MESH] |Cough/complications[MESH] |Female[MESH] |Fever/complications[MESH] |Lung/*diagnostic imaging/pathology/physiopathology/virology[MESH] |Macaca mulatta[MESH] |Male[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/*pathology/*physiopathology/virology[MESH] |Radiography[MESH] |Respiration Disorders/complications/*pathology/physiopathology/*virology[MESH] |SARS-CoV-2[MESH] |Time Factors[MESH]Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing