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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biodes+Manuf 2020 ; 3 (2): 83-86 Nephropedia Template TP
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Development of a rapid test kit for SARS-CoV-2: an example of product design #MMPMID32395391
Cui Z; Chang H; Wang H; Lim B; Hsu CC; Yu Y; Jia H; Wang Y; Zeng Y; Ji M; Liu W; Inverarity C; Huang WE
Biodes Manuf 2020[]; 3 (2): 83-86 PMID32395391show ga
We present an example of applying 'need-driven' product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.