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BCG-induced trained immunity: can it offer protection against COVID-19? #MMPMID32393823
O'Neill LAJ; Netea MG
Nat Rev Immunol 2020[Jun]; 20 (6): 335-337 PMID32393823show ga
Bacillus Calmette-Guerin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19.