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10.1186/s12933-020-01035-2

http://scihub22266oqcxt.onion/10.1186/s12933-020-01035-2
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32393351!7213552!32393351
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suck abstract from ncbi


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pmid32393351      Cardiovasc+Diabetol 2020 ; 19 (1): 58
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  • Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19 #MMPMID32393351
  • Ren H; Yang Y; Wang F; Yan Y; Shi X; Dong K; Yu X; Zhang S
  • Cardiovasc Diabetol 2020[May]; 19 (1): 58 PMID32393351show ga
  • BACKGROUND: The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. This study aims to evaluate the association of the TyG index with the severity and mortality of coronavirus disease 2019 (COVID-19). METHODS: The study included a cohort of 151 patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan. Regression models were used to investigate the association between TyG with severity and mortality of COVID-19. RESULTS: In this cohort, 39 (25.8%) patients had diabetes, 62 (41.1%) patients were severe cases, while 33 (22.0%) patients died in hospital. The TyG index levels were significantly higher in the severe cases and death group (mild vs. severe 8.7 +/- 0.6 vs. 9.2 +/- 0.6, P < 0.001; survivor vs. deceased 8.8 +/- 0.6 vs. 9.3 +/- 0.7, P < 0.001), respectively. The TyG index was significantly associated with an increased risk of severe case and mortality, after controlling for potential confounders (OR for severe case, 2.9, 95% CI 1.2-6.3, P = 0.007; OR for mortality, 2.9, 95% CI 1.2-6.7, P = 0.016). The associations were not statistically significant for further adjustment of inflammatory factors. CONCLUSION: TyG index was closely associated with the severity and morbidity in COVID-19 patients, thus it may be a valuable marker for identifying poor outcome of COVID-19.
  • |*Diabetes Complications/blood/diagnosis/mortality[MESH]
  • |*Insulin Resistance[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |Blood Glucose/*analysis[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*blood/*complications/diagnosis/mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*complications/diagnosis/mortality[MESH]
  • |Regression Analysis[MESH]
  • |Severity of Illness Index[MESH]


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