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10.1093/eurheartj/ehaa408

http://scihub22266oqcxt.onion/10.1093/eurheartj/ehaa408
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suck abstract from ncbi


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pmid32391877      Eur+Heart+J 2020 ; 41 (22): 2070-2079
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  • Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 #MMPMID32391877
  • Shi S; Qin M; Cai Y; Liu T; Shen B; Yang F; Cao S; Liu X; Xiang Y; Zhao Q; Huang H; Yang B; Huang C
  • Eur Heart J 2020[Jun]; 41 (22): 2070-2079 PMID32391877show ga
  • AIMS: To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). METHODS AND RESULTS: We enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regression models. A total of 62 patients (9.2%) died, who more often had myocardial injury (75.8% vs. 9.7%; P < 0.001) than survivors. The area under the receiver operating characteristic curve of initial cardiac troponin I (cTnI) for predicting in-hospital mortality was 0.92 [95% confidence interval (CI), 0.87-0.96; sensitivity, 0.86; specificity, 0.86; P < 0.001]. The single cut-off point and high level of cTnI predicted risk of in-hospital death, hazard ratio (HR) was 4.56 (95% CI, 1.28-16.28; P = 0.019) and 1.25 (95% CI, 1.07-1.46; P = 0.004), respectively. In multivariable logistic regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and high level of C-reactive protein were predictors of myocardial injury. CONCLUSION: The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/*complications/diagnosis/*mortality[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Heart Diseases/blood/diagnosis/mortality/*virology[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/*mortality[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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