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10.15698/mic2020.05.715

http://scihub22266oqcxt.onion/10.15698/mic2020.05.715
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32391393!7199282!32391393
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suck abstract from ncbi

pmid32391393      Microb+Cell 2020 ; 7 (5): 119-128
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  • Digesting the crisis: autophagy and coronaviruses #MMPMID32391393
  • Carmona-Gutierrez D; Bauer MA; Zimmermann A; Kainz K; Hofer SJ; Kroemer G; Madeo F
  • Microb Cell 2020[May]; 7 (5): 119-128 PMID32391393show ga
  • Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.
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