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10.1016/j.bbmt.2020.04.027 http://scihub22266oqcxt.onion/10.1016/j.bbmt.2020.04.027 32389803!7206419!32389803     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Blood+Marrow+Transplant 2020 ; 26 (7): e161-e166 Nephropedia Template TP {{tp|p=32389803|t=2020. Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia |pdf=|usr=}}{{32389803}} gab.com Text Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia JO: Biol Blood Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32389803 #FOAvip With the COVID-19 pandemic and the ensuing barriers to the collection and transport of donor cells, it is often necessary to collect and cryopreserve grafts before initiation of transplantation conditioning. The effect on transplantation outcomes in nonmalignant disease is unknown. This analysis examined the effect of cryopreservation of related and unrelated donor grafts for transplantation for severe aplastic anemia in the United States during 2013 to 2019. Included are 52 recipients of cryopreserved grafts who were matched for age, donor type, and graft type to 194 recipients who received noncryopreserved grafts. Marginal Cox regression models were built to study the effect of cryopreservation and other risk factors associated with outcomes. We recorded higher 1-year rates of graft failure (hazard ratio [HR], 2.26; 95% confidence interval, 1.17 to 4.35; P = .01) and of 1-year overall mortality (HR, 3.13; 95% CI, 1.60 to 6.11; P = .0008) after transplantation of cryopreserved compared with noncryopreserved grafts, with adjustment for sex, performance score, comorbidity, cytomegalovirus serostatus, and ABO blood group match. The incidence of acute and chronic graft-versus-host disease did not differ between the 2 groups. Adjusted probabilities of 1-year survival were 73% (95% CI, 60% to 84%) in the cryopreserved graft group and 91% (95% CI, 86% to 94%) in the noncryopreserved graft group. These data support the use of noncryopreserved grafts whenever possible in patients with severe aplastic anemia. Twit Text FOAVip Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia ????Biol Blood Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32389803 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32389803 #FOAvip English Wikipedia <ref>{{Cite pmid|32389803}}</ref> Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia #MMPMID32389803 Eapen M; Zhang MJ; Tang XY; Lee SJ; Fei MW; Wang HL; Hebert KM; Arora M; Chhabra S; Devine SM; Hamadani M; D'Souza A; Pasquini MC; Phelan R; Rizzo JD; Saber W; Shaw BE; Weisdorf DJ; Horowitz MM Biol Blood Marrow Transplant 2020[Jul]; 26 (7): e161-e166 PMID32389803show ga With the COVID-19 pandemic and the ensuing barriers to the collection and transport of donor cells, it is often necessary to collect and cryopreserve grafts before initiation of transplantation conditioning. The effect on transplantation outcomes in nonmalignant disease is unknown. This analysis examined the effect of cryopreservation of related and unrelated donor grafts for transplantation for severe aplastic anemia in the United States during 2013 to 2019. Included are 52 recipients of cryopreserved grafts who were matched for age, donor type, and graft type to 194 recipients who received noncryopreserved grafts. Marginal Cox regression models were built to study the effect of cryopreservation and other risk factors associated with outcomes. We recorded higher 1-year rates of graft failure (hazard ratio [HR], 2.26; 95% confidence interval, 1.17 to 4.35; P = .01) and of 1-year overall mortality (HR, 3.13; 95% CI, 1.60 to 6.11; P = .0008) after transplantation of cryopreserved compared with noncryopreserved grafts, with adjustment for sex, performance score, comorbidity, cytomegalovirus serostatus, and ABO blood group match. The incidence of acute and chronic graft-versus-host disease did not differ between the 2 groups. Adjusted probabilities of 1-year survival were 73% (95% CI, 60% to 84%) in the cryopreserved graft group and 91% (95% CI, 86% to 94%) in the noncryopreserved graft group. These data support the use of noncryopreserved grafts whenever possible in patients with severe aplastic anemia. |Acute Disease[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Anemia, Aplastic/immunology/mortality/pathology/*therapy[MESH] |Bone Marrow Transplantation/*methods[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Coronavirus Infections/*epidemiology[MESH] |Cryopreservation/*methods[MESH] |Female[MESH] |Graft Rejection/immunology/mortality/*pathology[MESH] |Graft vs Host Disease/immunology/mortality/*pathology[MESH] |Histocompatibility Testing[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peripheral Blood Stem Cell Transplantation/*methods[MESH] |Pneumonia, Viral/*epidemiology[MESH] |Retrospective Studies[MESH] |Siblings[MESH] |Survival Analysis[MESH] |Transplantation Conditioning/methods[MESH] |United States/epidemiology[MESH]Hematopoietic Cell Transplantation with Cryopreserved Grafts for Sever(epmc).pdf DeepDyve Pubget Overpricing