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10.1177/1932296820924469

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32389027!7673150!32389027
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suck abstract from ncbi


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pmid32389027      J+Diabetes+Sci+Technol 2020 ; 14 (4): 813-821
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  • Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States #MMPMID32389027
  • Bode B; Garrett V; Messler J; McFarland R; Crowe J; Booth R; Klonoff DC
  • J Diabetes Sci Technol 2020[Jul]; 14 (4): 813-821 PMID32389027show ga
  • INTRODUCTION: Diabetes has emerged as an important risk factor for severe illness and death from COVID-19. There is a paucity of information on glycemic control among hospitalized COVID-19 patients with diabetes and acute hyperglycemia. METHODS: This retrospective observational study of laboratory-confirmed COVID-19 adults evaluated glycemic and clinical outcomes in patients with and without diabetes and/or acutely uncontrolled hyperglycemia hospitalized March 1 to April 6, 2020. Diabetes was defined as A1C >/=6.5%. Uncontrolled hyperglycemia was defined as >/=2 blood glucoses (BGs) > 180 mg/dL within any 24-hour period. Data were abstracted from Glytec's data warehouse. RESULTS: Among 1122 patients in 88 U.S. hospitals, 451 patients with diabetes and/or uncontrolled hyperglycemia spent 37.8% of patient days having a mean BG > 180 mg/dL. Among 570 patients who died or were discharged, the mortality rate was 28.8% in 184 diabetes and/or uncontrolled hyperglycemia patients, compared with 6.2% of 386 patients without diabetes or hyperglycemia (P < .001). Among the 184 patients with diabetes and/or hyperglycemia who died or were discharged, 40 of 96 uncontrolled hyperglycemia patients (41.7%) died compared with 13 of 88 patients with diabetes (14.8%, P < .001). Among 493 discharged survivors, median length of stay (LOS) was longer in 184 patients with diabetes and/or uncontrolled hyperglycemia compared with 386 patients without diabetes or hyperglycemia (5.7 vs 4.3 days, P < .001). CONCLUSION: Among hospitalized patients with COVID-19, diabetes and/or uncontrolled hyperglycemia occurred frequently. These COVID-19 patients with diabetes and/or uncontrolled hyperglycemia had a longer LOS and markedly higher mortality than patients without diabetes or uncontrolled hyperglycemia. Patients with uncontrolled hyperglycemia had a particularly high mortality rate. We recommend health systems which ensure that inpatient hyperglycemia is safely and effectively treated.
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |Blood Glucose Self-Monitoring/methods[MESH]
  • |COVID-19[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*complications/epidemiology/*therapy[MESH]
  • |Data Collection[MESH]
  • |Female[MESH]
  • |Glycated Hemoglobin/analysis[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hyperglycemia/complications/epidemiology/*therapy[MESH]
  • |Insulin Infusion Systems[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Patient Discharge[MESH]
  • |Pneumonia, Viral/*complications/epidemiology/*therapy[MESH]
  • |Respiratory Distress Syndrome/complications[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Software[MESH]
  • |Treatment Outcome[MESH]


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