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10.1016/j.dsx.2020.04.040 http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.04.040 32388330!7198998!32388330     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+Syndr 2020 ; 14 (4): 509-512 Nephropedia Template TP {{tp|p=32388330|t=2020. Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19 A mini-review |pdf=|usr=}}{{32388330}} gab.com Text Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19 A mini-review JO: Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32388330 #FOAvip BACKGROUND: Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19. METHODS: A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications. RESULTS: The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury. CONCLUSIONS: Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury. Twit Text FOAVip Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19 A mini-review ????Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32388330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32388330 #FOAvip English Wikipedia <ref>{{Cite pmid|32388330}}</ref> Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19 A mini-review #MMPMID32388330 Nakhleh A; Shehadeh N Diabetes Metab Syndr 2020[Jul]; 14 (4): 509-512 PMID32388330show ga BACKGROUND: Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19. METHODS: A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications. RESULTS: The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury. CONCLUSIONS: Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury. |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH] |Betacoronavirus/*pathogenicity[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*complications/drug therapy/transmission/virology[MESH] |Host-Pathogen Interactions/*drug effects[MESH] |Humans[MESH] |Hypoglycemic Agents/*therapeutic use[MESH] |Lung Diseases/*drug therapy/etiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/transmission/virology[MESH] |Renin-Angiotensin System/*drug effects[MESH]Interactions between antihyperglycemic drugs and the renin-angiotensin(epmc).pdf DeepDyve Pubget Overpricing