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10.1016/j.coi.2020.03.013 http://scihub22266oqcxt.onion/10.1016/j.coi.2020.03.013 32387642!7174181!32387642     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2020 ; 65 (ä): 50-56 Nephropedia Template TP {{tp|p=32387642|t=2020. Innovations in structure-based antigen design and immune monitoring for next generation vaccines |pdf=|usr=}}{{32387642}} gab.com Text Innovations in structure-based antigen design and immune monitoring for next generation vaccines JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32387642 #FOAvip The recent explosion of atomic-level structures of glycoproteins that comprise the surface antigens of human enveloped viruses, such as RSV, influenza, and HIV, provide tremendous opportunities for rational, structure-based vaccine design. Several concepts in structure-based vaccine design have been put into practice and are are well along preclinical and clinical implementation. Testing of these designed immunogens will provide key insights into the ability to induce the desired immune responses, namely neutralizing antibodies. Many of these immunogens in human clinical trials represent only the first wave of designs and will likely require continued tweaking and elaboration to achieve the ultimate goal of enhanced breadth and potency. Considerable effort is now being invested in germline targeting, epitope focusing, and improved immune presentation such as multivalent nanoparticle incorporation. This review highlights some of the recent advances in these areas as we prepare for the next generation of immunogens for subsequent rounds of iterative vaccine development. Twit Text FOAVip Innovations in structure-based antigen design and immune monitoring for next generation vaccines ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32387642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32387642 #FOAvip English Wikipedia <ref>{{Cite pmid|32387642}}</ref> Innovations in structure-based antigen design and immune monitoring for next generation vaccines #MMPMID32387642 Ward AB; Wilson IA Curr Opin Immunol 2020[Aug]; 65 (ä): 50-56 PMID32387642show ga The recent explosion of atomic-level structures of glycoproteins that comprise the surface antigens of human enveloped viruses, such as RSV, influenza, and HIV, provide tremendous opportunities for rational, structure-based vaccine design. Several concepts in structure-based vaccine design have been put into practice and are are well along preclinical and clinical implementation. Testing of these designed immunogens will provide key insights into the ability to induce the desired immune responses, namely neutralizing antibodies. Many of these immunogens in human clinical trials represent only the first wave of designs and will likely require continued tweaking and elaboration to achieve the ultimate goal of enhanced breadth and potency. Considerable effort is now being invested in germline targeting, epitope focusing, and improved immune presentation such as multivalent nanoparticle incorporation. This review highlights some of the recent advances in these areas as we prepare for the next generation of immunogens for subsequent rounds of iterative vaccine development. |*Models, Molecular[MESH] |*Vaccinology/methods/trends[MESH] |Animals[MESH] |Antigens/*chemistry/genetics/*immunology[MESH] |Cross Reactions/immunology[MESH] |Epitopes/*chemistry/genetics/*immunology[MESH] |Germ Cells/immunology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Models, Animal[MESH] |Mutation[MESH] |Structure-Activity Relationship[MESH]Innovations in structure-based antigen design and immune monitoring fo(epmc).pdf DeepDyve Pubget Overpricing