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10.1016/j.autrev.2020.102573

http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102573
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32387470!7199723!32387470
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suck abstract from ncbi


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pmid32387470      Autoimmun+Rev 2020 ; 19 (7): 102573
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  • COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome? #MMPMID32387470
  • Colafrancesco S; Alessandri C; Conti F; Priori R
  • Autoimmun Rev 2020[Jul]; 19 (7): 102573 PMID32387470show ga
  • The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndromes" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes" which would allow considering severe COVID-19 as a fifth member of this spectrum of inflammatory conditions.
  • |Antiphospholipid Syndrome[MESH]
  • |Betacoronavirus[MESH]
  • |Blood Coagulation Disorders[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*physiopathology[MESH]
  • |Cytokine Release Syndrome/immunology/virology[MESH]
  • |Ferritins[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Macrophage Activation Syndrome[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*physiopathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Shock, Septic[MESH]


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