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10.1016/j.micinf.2020.05.002 http://scihub22266oqcxt.onion/10.1016/j.micinf.2020.05.002 32387333!7200356!32387333     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbes+Infect 2020 ; 22 (4-5): 168-171 Nephropedia Template TP {{tp|p=32387333|t=2020. Could nasal nitric oxide help to mitigate the severity of COVID-19?|pdf=|usr=}}{{32387333}} gab.com Text Could nasal nitric oxide help to mitigate the severity of COVID-19 JO: Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32387333 #FOAvip The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce bronchodilatory and vasodilatory effects. Studies indicate that NO may also help to reduce respiratory tract infection by inactivating viruses and inhibiting their replication in epithelial cells. In view of the pandemic caused by the novel coronavirus (SARS-CoV-2), clinical trials have been designed to examine the effects of inhaled nitric oxide in COVID-19 subjects. We discuss here additional lifestyle factors such as mouth breathing which may affect the antiviral response against SARS-CoV-2 by bypassing the filtering effect of the nose and by decreasing NO levels in the airways. Simple devices that promote nasal breathing during sleep may help prevent the common cold, suggesting potential benefits against coronavirus infection. In the absence of effective treatments against COVID-19, the alternative strategies proposed here should be considered and studied in more detail. Twit Text FOAVip Could nasal nitric oxide help to mitigate the severity of COVID-19 ????Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32387333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32387333 #FOAvip English Wikipedia <ref>{{Cite pmid|32387333}}</ref> Could nasal nitric oxide help to mitigate the severity of COVID-19? #MMPMID32387333 Martel J; Ko YF; Young JD; Ojcius DM Microbes Infect 2020[May]; 22 (4-5): 168-171 PMID32387333show ga The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce bronchodilatory and vasodilatory effects. Studies indicate that NO may also help to reduce respiratory tract infection by inactivating viruses and inhibiting their replication in epithelial cells. In view of the pandemic caused by the novel coronavirus (SARS-CoV-2), clinical trials have been designed to examine the effects of inhaled nitric oxide in COVID-19 subjects. We discuss here additional lifestyle factors such as mouth breathing which may affect the antiviral response against SARS-CoV-2 by bypassing the filtering effect of the nose and by decreasing NO levels in the airways. Simple devices that promote nasal breathing during sleep may help prevent the common cold, suggesting potential benefits against coronavirus infection. In the absence of effective treatments against COVID-19, the alternative strategies proposed here should be considered and studied in more detail. |*Betacoronavirus/drug effects[MESH] |Administration, Intranasal[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/prevention & control[MESH] |Humans[MESH] |Nitric Oxide/*administration & dosage/*therapeutic use[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/*drug therapy/prevention & control[MESH] |SARS-CoV-2[MESH]Could nasal nitric oxide help to mitigate the severity of COVID-19?(epmc).pdf DeepDyve Pubget Overpricing