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10.1016/j.medmal.2020.05.001

http://scihub22266oqcxt.onion/10.1016/j.medmal.2020.05.001
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32387320!7202806!32387320
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suck abstract from ncbi


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pmid32387320      Med+Mal+Infect 2020 ; 50 (5): 397-400
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  • Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients #MMPMID32387320
  • Klopfenstein T; Zayet S; Lohse A; Balblanc JC; Badie J; Royer PY; Toko L; Mezher C; Kadiane-Oussou NJ; Bossert M; Bozgan AM; Charpentier A; Roux MF; Contreras R; Mazurier I; Dussert P; Gendrin V; Conrozier T
  • Med Mal Infect 2020[Aug]; 50 (5): 397-400 PMID32387320show ga
  • INTRODUCTION: No therapy has yet proven effective in COVID-19. Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. METHOD: We conducted a retrospective case-control study in the Nord Franche-Comte Hospital, France. We compared the outcome of patients treated with TCZ and patients without TCZ considering a combined primary endpoint: death and/or ICU admissions. RESULTS: Patients with TCZ (n=20) had a higher Charlson comorbidity index (5.3 [+/-2.4] vs 3.4 [+/-2.6], P=0.014), presented with more severe forms (higher level of oxygen therapy at 13L/min vs 6L/min, P<0.001), and had poorer biological findings (severe lymphopenia: 676/mm(3) vs 914/mm(3), P=0.037 and higher CRP level: 158mg/L vs 105mg/L, P=0.017) than patients without TCZ (n=25). However, death and/or ICU admissions were higher in patients without TCZ than in the TCZ group (72% vs 25%, P=0.002). CONCLUSION: Despite the small sample size and retrospective nature of the work, this result strongly suggests that TCZ may reduce the number of ICU admissions and/or mortality in patients with severe SARS-CoV-2 pneumonia.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects/immunology[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*drug therapy/*epidemiology/*mortality/pathology[MESH]
  • |Critical Illness/epidemiology/mortality[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/*statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality[MESH]
  • |Pandemics[MESH]
  • |Patient Admission/*statistics & numerical data[MESH]
  • |Pneumonia, Viral/*drug therapy/*epidemiology/*mortality/pathology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Treatment Outcome[MESH]


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