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10.1080/22221751.2020.1761267

http://scihub22266oqcxt.onion/10.1080/22221751.2020.1761267
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32380903!7241448!32380903
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suck abstract from ncbi


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pmid32380903      Emerg+Microbes+Infect 2020 ; 9 (1): 900-902
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  • Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2 #MMPMID32380903
  • Anderson DE; Tan CW; Chia WN; Young BE; Linster M; Low JH; Tan YJ; Chen MI; Smith GJD; Leo YS; Lye DC; Wang LF
  • Emerg Microbes Infect 2020[Dec]; 9 (1): 900-902 PMID32380903show ga
  • Despite initial findings indicating that SARS-CoV and SARS-CoV-2 are genetically related belonging to the same virus species and that the two viruses used the same entry receptor, angiotensin-converting enzyme 2 (ACE2), our data demonstrated that there is no detectable cross-neutralization by SARS patient sera against SARS-CoV-2. We also found that there are significant levels of neutralizing antibodies in recovered SARS patients 9-17 years after initial infection. These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy.
  • |Antibodies, Viral/*blood[MESH]
  • |Betacoronavirus/immunology[MESH]
  • |Broadly Neutralizing Antibodies/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Coronavirus Infections/*immunology/therapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/standards[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/*immunology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/*immunology[MESH]
  • |Time Factors[MESH]


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