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Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2 #MMPMID32380903
Anderson DE; Tan CW; Chia WN; Young BE; Linster M; Low JH; Tan YJ; Chen MI; Smith GJD; Leo YS; Lye DC; Wang LF
Emerg Microbes Infect 2020[Dec]; 9 (1): 900-902 PMID32380903show ga
Despite initial findings indicating that SARS-CoV and SARS-CoV-2 are genetically related belonging to the same virus species and that the two viruses used the same entry receptor, angiotensin-converting enzyme 2 (ACE2), our data demonstrated that there is no detectable cross-neutralization by SARS patient sera against SARS-CoV-2. We also found that there are significant levels of neutralizing antibodies in recovered SARS patients 9-17 years after initial infection. These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy.