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10.1016/j.autrev.2020.102566

http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102566
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32380315!7198406!32380315
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suck abstract from ncbi


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pmid32380315      Autoimmun+Rev 2020 ; 19 (7): 102566
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  • Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis #MMPMID32380315
  • Gendelman O; Amital H; Bragazzi NL; Watad A; Chodick G
  • Autoimmun Rev 2020[Jul]; 19 (7): 102566 PMID32380315show ga
  • BACKGROUND: Some disease-modifying agents commonly used to treat patients with rheumatic diseases/autoimmune disorders, such as hydroxychloroquine and colchicine, are under investigation as potential therapies for the "coronavirus disease 2019" (COVID-19). However, the role of such agents as prophylactic tools is still not clear. METHODS: This is a retrospective study based on a large healthcare computerized database including all patients that were screened for the "Severe Acute Respiratory Syndrome Coronavirus type 2" (SARS-CoV-2) in the study period from February 23rd 2020 to March 31st 2020. A comparison was conducted between subjects tested positive for SARS-CoV-2 and those found negative in terms of rate of administration of hydroxychloroquine/colchicine therapy. RESULTS: An overall sample of 14,520 subjects were screened for SARS-CoV-2 infection and 1317 resulted positive. No significant difference was found in terms of rates of usage of hydroxychloroquine or colchicine between those who were found positive for SARS-CoV-2 and those who were found negative (0.23% versus 0.25% for hydroxychloroquine, and 0.53% versus 0.48% for colchicine, respectively). CONCLUSION: These findings raise doubts regarding the protective role of these medications in the battle against SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Chemoprevention[MESH]
  • |Colchicine/*therapeutic use[MESH]
  • |Coronavirus Infections/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Israel[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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