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10.1002/1873-3468.13806

http://scihub22266oqcxt.onion/10.1002/1873-3468.13806
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32379896!7267562!32379896
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suck abstract from ncbi


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pmid32379896      FEBS+Lett 2020 ; 594 (12): 1960-1973
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  • Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs #MMPMID32379896
  • Hijikata A; Shionyu-Mitsuyama C; Nakae S; Shionyu M; Ota M; Kanaya S; Shirai T
  • FEBS Lett 2020[Jun]; 594 (12): 1960-1973 PMID32379896show ga
  • The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 a pandemic. There is, however, no confirmed anti-COVID-19 therapeutic currently. In order to assist structure-based discovery efforts for repurposing drugs against this disease, we constructed knowledge-based models of SARS-CoV-2 proteins and compared the ligand molecules in the template structures with approved/experimental drugs and components of natural medicines. Our theoretical models suggest several drugs, such as carfilzomib, sinefungin, tecadenoson, and trabodenoson, that could be further investigated for their potential for treating COVID-19.
  • |Antiviral Agents/*metabolism/pharmacology[MESH]
  • |Betacoronavirus/drug effects/*metabolism[MESH]
  • |Models, Molecular[MESH]
  • |Protein Conformation[MESH]
  • |SARS-CoV-2[MESH]


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