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10.1111/ajt.15982

http://scihub22266oqcxt.onion/10.1111/ajt.15982
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32378314!7267352!32378314
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suck abstract from ncbi


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pmid32378314      Am+J+Transplant 2020 ; 20 (10): 2916-2922
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  • Early experience of COVID-19 in 2 heart transplant recipients: Case reports and review of treatment options #MMPMID32378314
  • Holzhauser L; Lourenco L; Sarswat N; Kim G; Chung B; Nguyen AB
  • Am J Transplant 2020[Oct]; 20 (10): 2916-2922 PMID32378314show ga
  • The coronavirus disease 2019 (COVID-19) pandemic poses special challenges to immunocompromised transplant patients. Given the paucity of proven data in treating COVID-19, management of these patients is difficult, rapidly evolving, and mainly based on anecdotal experience. We report 2 cases of heart transplant (HT) recipients with COVID-19. The first is a 59-year-old female with HT in 2012 who presented on March 20, 2020 with fever, hypoxia, and ground-glass opacities on chest X-ray. She quickly progressed to acute hypoxic respiratory failure and vasoplegic shock. Despite reduction in immunosuppression and treatment with tocilizumab, intravenous immunoglobulin, hydroxychloroquine, lopinavir/ritonavir, and broad-spectrum antibiotics, she ultimately died from multiorgan failure. The second case is a 75-year-old man with HT in 2000 who presented on April 2, 2020 after curbside testing revealed positive COVID-19. Given a milder presentation compared to the first patient, antimetabolite was discontinued and only hydroxychloroquine was started. Because of a lack of clinical improvement several days later, tocilizumab, methylprednisolone, and therapeutic anticoagulation were initiated. The patient clinically improved with decreasing oxygen requirements and was discharged home. These 2 cases highlight the wide range of different presentations of COVID-19 in HT recipients and the rapidity with which the management of these patients is evolving.
  • |*Betacoronavirus[MESH]
  • |*Transplant Recipients[MESH]
  • |Aged[MESH]
  • |COVID-19[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*epidemiology[MESH]
  • |Fatal Outcome[MESH]
  • |Female[MESH]
  • |Graft Rejection/*prevention & control[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Immunosuppression Therapy/methods[MESH]
  • |Immunosuppressive Agents/*therapeutic use[MESH]
  • |Kidney Failure, Chronic/epidemiology/*surgery[MESH]
  • |Kidney Transplantation/*adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology[MESH]


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