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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Mol+Med 2020 ; 46 (1): 3-16 Nephropedia Template TP
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Towards effective COVID?19 vaccines: Updates, perspectives and challenges (Review) #MMPMID32377694
Calina D; Docea AO; Petrakis D; Egorov AM; Ishmukhametov AA; Gabibov AG; Shtilman MI; Kostoff R; Carvalho F; Vinceti M; Spandidos DA; Tsatsakis A
Int J Mol Med 2020[Jul]; 46 (1): 3-16 PMID32377694show ga
In the current context of the pandemic triggered by SARS-COV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS?COV?2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a COVID?19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.