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10.1016/j.autrev.2020.102575

http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102575
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32376395!7200134!32376395
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suck abstract from ncbi


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pmid32376395      Autoimmun+Rev 2020 ; 19 (7): 102575
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  • SARS-CoV-2 infection among patients with systemic autoimmune diseases #MMPMID32376395
  • Emmi G; Bettiol A; Mattioli I; Silvestri E; Di Scala G; Urban ML; Vaglio A; Prisco D
  • Autoimmun Rev 2020[Jul]; 19 (7): 102575 PMID32376395show ga
  • OBJECTIVES: This study aimed to evaluate the prevalence of clinically overt SARS-CoV-2 infection (COVID-19) among patients with systemic autoimmune diseases residing in Tuscany, and to compare it with that observed in the general Tuscan population. METHODS: In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection. RESULTS: 458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. Of them, 7 had undergone nasopharyngeal swab and only one was positive and developed severe SARS-CoV-2 complications. Within our cohort, the prevalence of SARS-CoV-2 infection was therefore 0.22% (0.01-1.21%), comparable to that observed in the general population of Tuscany [0.20% (0.20-0.21%), p = .597]. CONCLUSIONS: Patients with systemic autoimmune diseases do not seem to carry an increased risk of SARS- CoV-2 infection as compared to the general population.
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antirheumatic Agents/therapeutic use[MESH]
  • |Autoimmune Diseases/*complications/drug therapy[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Colchicine/therapeutic use[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications[MESH]


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