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10.1016/j.autrev.2020.102569

http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102569
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32376394!7252146!32376394
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suck abstract from ncbi


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pmid32376394      Autoimmun+Rev 2020 ; 19 (7): 102569
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  • Immunomodulatory therapy for the management of severe COVID-19 Beyond the anti-viral therapy: A comprehensive review #MMPMID32376394
  • Alijotas-Reig J; Esteve-Valverde E; Belizna C; Selva-O'Callaghan A; Pardos-Gea J; Quintana A; Mekinian A; Anunciacion-Llunell A; Miro-Mur F
  • Autoimmun Rev 2020[Jul]; 19 (7): 102569 PMID32376394show ga
  • Severe Acute Respiratory Syndrome related to Coronavirus-2 (SARS-CoV-2), coronavirus disease-2019 (COVID-19) may cause severe illness in 20% of patients. This may be in part due to an uncontrolled immune-response to SARS-CoV-2 infection triggering a systemic hyperinflammatory response, the so-called "cytokine storm". The reduction of this inflammatory immune-response could be considered as a potential therapeutic target against severe COVID-19. The relationship between inflammation and clot activation must also be considered. Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. However, right data on the effectiveness of different immunomodulating drugs are scarce. Herein, we discuss the pathogenesis and the possible role played by drugs such as: antimalarials, anti-IL6, anti-IL-1, calcineurin and JAK inhibitors, corticosteroids, immunoglobulins, heparins, angiotensin-converting enzyme agonists and statins in severe COVID-19.
  • |*Immunomodulation[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH]
  • |Anticoagulants/therapeutic use[MESH]
  • |Antimalarials/therapeutic use[MESH]
  • |Antiviral Agents[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*therapy[MESH]
  • |Cytokines/antagonists & inhibitors[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]
  • |Janus Kinases/antagonists & inhibitors[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*therapy[MESH]
  • |Risk Factors[MESH]


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