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10.1016/j.autrev.2020.102569 http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102569 32376394!7252146!32376394     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32376394.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autoimmun+Rev 2020 ; 19 (7): 102569 Nephropedia Template TP {{tp|p=32376394|t=2020. Immunomodulatory therapy for the management of severe COVID-19 Beyond the anti-viral therapy: A comprehensive review |pdf=|usr=}}{{32376394}} gab.com Text Immunomodulatory therapy for the management of severe COVID-19 Beyond the anti-viral therapy: A comprehensive review JO: Autoimmun Rev http://www.kidney.de/pget.php?&tw=1&pmid=32376394 #FOAvip Severe Acute Respiratory Syndrome related to Coronavirus-2 (SARS-CoV-2), coronavirus disease-2019 (COVID-19) may cause severe illness in 20% of patients. This may be in part due to an uncontrolled immune-response to SARS-CoV-2 infection triggering a systemic hyperinflammatory response, the so-called "cytokine storm". The reduction of this inflammatory immune-response could be considered as a potential therapeutic target against severe COVID-19. The relationship between inflammation and clot activation must also be considered. Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. However, right data on the effectiveness of different immunomodulating drugs are scarce. Herein, we discuss the pathogenesis and the possible role played by drugs such as: antimalarials, anti-IL6, anti-IL-1, calcineurin and JAK inhibitors, corticosteroids, immunoglobulins, heparins, angiotensin-converting enzyme agonists and statins in severe COVID-19. Twit Text FOAVip Immunomodulatory therapy for the management of severe COVID-19 Beyond the anti-viral therapy: A comprehensive review ????Autoimmun Rev http://www.kidney.de/pget.php?&tw=1&pmid=32376394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32376394 #FOAvip English Wikipedia <ref>{{Cite pmid|32376394}}</ref> Immunomodulatory therapy for the management of severe COVID-19 Beyond the anti-viral therapy: A comprehensive review #MMPMID32376394 Alijotas-Reig J; Esteve-Valverde E; Belizna C; Selva-O'Callaghan A; Pardos-Gea J; Quintana A; Mekinian A; Anunciacion-Llunell A; Miro-Mur F Autoimmun Rev 2020[Jul]; 19 (7): 102569 PMID32376394show ga Severe Acute Respiratory Syndrome related to Coronavirus-2 (SARS-CoV-2), coronavirus disease-2019 (COVID-19) may cause severe illness in 20% of patients. This may be in part due to an uncontrolled immune-response to SARS-CoV-2 infection triggering a systemic hyperinflammatory response, the so-called "cytokine storm". The reduction of this inflammatory immune-response could be considered as a potential therapeutic target against severe COVID-19. The relationship between inflammation and clot activation must also be considered. Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. However, right data on the effectiveness of different immunomodulating drugs are scarce. Herein, we discuss the pathogenesis and the possible role played by drugs such as: antimalarials, anti-IL6, anti-IL-1, calcineurin and JAK inhibitors, corticosteroids, immunoglobulins, heparins, angiotensin-converting enzyme agonists and statins in severe COVID-19. |*Immunomodulation[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Anticoagulants/therapeutic use[MESH] |Antimalarials/therapeutic use[MESH] |Antiviral Agents[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*therapy[MESH] |Cytokines/antagonists & inhibitors[MESH] |Glucocorticoids/therapeutic use[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use[MESH] |Immunoglobulins, Intravenous/therapeutic use[MESH] |Janus Kinases/antagonists & inhibitors[MESH] |Pandemics[MESH] |Pneumonia, Viral/*therapy[MESH] |Risk Factors[MESH]Immunomodulatory therapy for the management of severe COVID-19 Beyond(epmc).pdf DeepDyve Pubget Overpricing