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10.1016/j.carpath.2020.107228

http://scihub22266oqcxt.onion/10.1016/j.carpath.2020.107228
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suck abstract from ncbi


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pmid32375085      Cardiovasc+Pathol 2020 ; 47 (ä): 107228
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  • Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019 #MMPMID32375085
  • Geng YJ; Wei ZY; Qian HY; Huang J; Lodato R; Castriotta RJ
  • Cardiovasc Pathol 2020[Jul]; 47 (ä): 107228 PMID32375085show ga
  • The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen. Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death. Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications. Acting as the receptor for SARS-CoV entering mammalian cells, angiotensin converting enzyme-2 (ACE2) plays a pivotal role in the regulation of cardiovascular cell function. Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/*virology[MESH]
  • |Coronavirus Infections/*complications/*physiopathology/therapy[MESH]
  • |Humans[MESH]
  • |Lung Injury/*virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*physiopathology/therapy[MESH]


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