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10.1111/ijcp.13525 http://scihub22266oqcxt.onion/10.1111/ijcp.13525 32374903!7267315!32374903     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Pract 2020 ; 74 (8): e13525 Nephropedia Template TP {{tp|p=32374903|t=2020. SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate |pdf=|usr=}}{{32374903}} gab.com Text SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate JO: Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32374903 #FOAvip AIM: The COVID-19 pandemic is caused by infection with the SARS-CoV-2 virus. The major mutation detected to date in the SARS-CoV-2 viral envelope spike protein, which is responsible for virus attachment to the host and is also the main target for host antibodies, is a mutation of an aspartate (D) at position 614 found frequently in Chinese strains to a glycine (G). We sought to infer health impact of this mutation. RESULT: Increased case fatality rate correlated strongly with the proportion of viruses bearing G614 on a country by country basis. The amino acid at position 614 occurs at an internal protein interface of the viral spike, and the presence of G at this position was calculated to destabilise a specific conformation of the viral spike, within which the key host receptor binding site is more accessible. CONCLUSION: These results imply that G614 is a more pathogenic strain of SARS-CoV-2, which may influence vaccine design. The prevalence of this form of the virus should also be included in epidemiologic models predicting the COVID-19 health burden and fatality over time in specific regions. Physicians should be aware of this characteristic of the virus to anticipate the clinical course of infection. Twit Text FOAVip SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate ????Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32374903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32374903 #FOAvip English Wikipedia <ref>{{Cite pmid|32374903}}</ref> SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate #MMPMID32374903 Becerra-Flores M; Cardozo T Int J Clin Pract 2020[Aug]; 74 (8): e13525 PMID32374903show ga AIM: The COVID-19 pandemic is caused by infection with the SARS-CoV-2 virus. The major mutation detected to date in the SARS-CoV-2 viral envelope spike protein, which is responsible for virus attachment to the host and is also the main target for host antibodies, is a mutation of an aspartate (D) at position 614 found frequently in Chinese strains to a glycine (G). We sought to infer health impact of this mutation. RESULT: Increased case fatality rate correlated strongly with the proportion of viruses bearing G614 on a country by country basis. The amino acid at position 614 occurs at an internal protein interface of the viral spike, and the presence of G at this position was calculated to destabilise a specific conformation of the viral spike, within which the key host receptor binding site is more accessible. CONCLUSION: These results imply that G614 is a more pathogenic strain of SARS-CoV-2, which may influence vaccine design. The prevalence of this form of the virus should also be included in epidemiologic models predicting the COVID-19 health burden and fatality over time in specific regions. Physicians should be aware of this characteristic of the virus to anticipate the clinical course of infection. |*Mutation[MESH] |Aspartic Acid[MESH] |Betacoronavirus/*genetics/pathogenicity[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/*mortality[MESH] |Glycine[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*mortality[MESH] |SARS-CoV-2[MESH]SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rat(epmc).pdf DeepDyve Pubget Overpricing