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10.1002/jmv.25976 http://scihub22266oqcxt.onion/10.1002/jmv.25976 32374452!7267556!32374452     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (9): 1690-1694 Nephropedia Template TP {{tp|p=32374452|t=2020. SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein |pdf=|usr=}}{{32374452}} gab.com Text SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32374452 #FOAvip To investigate the evolutionary history of the current pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a total of 137 genomes of coronavirus strains with release dates between January 2019 and 25 March 2020, were analyzed. To investigate the potential intermediate host of the SARS-CoV-2, we analyzed spike glycoprotein sequences from different animals, with particular emphasis on bats. We performed phylogenetic analysis and structural reconstruction of the spike glycoproteins with subsequent alignment and comparison. Our phylogenetic results revealed that SARS-CoV-2 was more similar to the bats' betacoronavirus isolates: HKU5-related from Pipistrellus abramus and HKU4-related from Tylonycteris pachypus. We also identified a yak betacoronavirus strain, YAK/HY24/CH/2017, as the closest match in the comparison of the structural models of spike glycoproteins. Interestingly, a set of unique features has been described for this particular strain of the yak betacoronavirus. Therefore, our results suggest that the human SARS-CoV-2, responsible for the current outbreak of COVID-19, could also come from yak as an intermediate host. Twit Text FOAVip SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32374452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32374452 #FOAvip English Wikipedia <ref>{{Cite pmid|32374452}}</ref> SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein #MMPMID32374452 Dabravolski SA; Kavalionak YK J Med Virol 2020[Sep]; 92 (9): 1690-1694 PMID32374452show ga To investigate the evolutionary history of the current pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a total of 137 genomes of coronavirus strains with release dates between January 2019 and 25 March 2020, were analyzed. To investigate the potential intermediate host of the SARS-CoV-2, we analyzed spike glycoprotein sequences from different animals, with particular emphasis on bats. We performed phylogenetic analysis and structural reconstruction of the spike glycoproteins with subsequent alignment and comparison. Our phylogenetic results revealed that SARS-CoV-2 was more similar to the bats' betacoronavirus isolates: HKU5-related from Pipistrellus abramus and HKU4-related from Tylonycteris pachypus. We also identified a yak betacoronavirus strain, YAK/HY24/CH/2017, as the closest match in the comparison of the structural models of spike glycoproteins. Interestingly, a set of unique features has been described for this particular strain of the yak betacoronavirus. Therefore, our results suggest that the human SARS-CoV-2, responsible for the current outbreak of COVID-19, could also come from yak as an intermediate host. |Animals[MESH] |COVID-19/*virology[MESH] |Genome, Viral[MESH] |Genomics/methods[MESH] |Host Specificity[MESH] |Humans[MESH] |Models, Molecular[MESH] |Phylogeny[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*classification/*physiology/ultrastructure[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH] |Structure-Activity Relationship[MESH] |Viral Tropism[MESH]SARS-CoV-2: Structural diversity, phylogeny, and potential animal host(epmc).pdf DeepDyve Pubget Overpricing